Adaptive disinhibitory gating by VIP interneurons permits associative learning
نویسندگان
چکیده
منابع مشابه
A dendritic disinhibitory circuit mechanism for pathway-specific gating
While reading a book in a noisy café, how does your brain 'gate in' visual information while filtering out auditory stimuli? Here we propose a mechanism for such flexible routing of information flow in a complex brain network (pathway-specific gating), tested using a network model of pyramidal neurons and three classes of interneurons with connection probabilities constrained by data. We find t...
متن کاملDisinhibitory gating of retinal output by transmission from an amacrine cell.
Inhibitory interneurons help transform the input of a neural circuit into its output. Such interneurons are diverse, and most have unknown function. To study the function of single amacrine cells in the intact salamander retina, we recorded extracellularly from a population of ganglion cells with a multielectrode array, while simultaneously recording from or injecting current into single Off-ty...
متن کاملThalamic Gating of Corticostriatal Signaling by Cholinergic Interneurons
Salient stimuli redirect attention and suppress ongoing motor activity. This attentional shift is thought to rely upon thalamic signals to the striatum to shift cortically driven action selection, but the network mechanisms underlying this interaction are unclear. Using a brain slice preparation that preserved cortico- and thalamostriatal connectivity, it was found that activation of thalamostr...
متن کاملDevelopmental Dysfunction of VIP Interneurons Impairs Cortical Circuits.
GABAergic interneurons play important roles in cortical circuit development. However, there are multiple populations of interneurons and their respective developmental contributions remain poorly explored. Neuregulin 1 (NRG1) and its interneuron-specific receptor ERBB4 are critical genes for interneuron maturation. Using a conditional ErbB4 deletion, we tested the role of vasoactive intestinal ...
متن کاملVision and locomotion shape the interactions between neuron types in mouse visual cortex
Locomotion profoundly changes sensory responses in mouse primary visual cortex. These changes are thought to arise from a disinhibitory circuit, whereby interneurons expressing vasoactive intestinal peptide (Vip) inhibit those expressing somatostatin (Sst), thus disinhibiting pyramidal cells (Pyr). We studied the effect of locomotion on these cell types and on interneurons expressing parvalbumi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2019
ISSN: 1097-6256,1546-1726
DOI: 10.1038/s41593-019-0508-y